I would think her role in True Blood would be considered as big as being the Trinity Killer's daughter in Dexter. But yeah, if even you thought it was a reference to a previous ep rather than a cameo, I'm sure more casual TV watchers would be confused as hell. If this was a show like Entourage, this would make sense, because you kinda expect it. Well, that, or if she was involved with one of the cast members or crew. But since she (and I guess Brandon Routh) are not, it seems totally random!